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The glucagon receptor component also drives metabolic benefits that operate independently of weight loss cardiovascular risk marker improvements including non-HDL cholesterol reduction, triglyceride reduction, high-sensitivity C-reactive protein reduction, and at the highest dose, a 14mmHg reduction in systolic blood pressure

Not on current evidence

In clinical trials, these events occurred at rates similar to placebo groups, suggesting the medication itself may not directly cause them

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Many users also present with hypertension, sleep apnea or other conditions that strengthen the case for structured care